Ubiquitin, Autophagy and Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Ubiquitin, lysosomes, and neurodegenerative diseases.
Ubiquitin, lysosomes and neurodegenerative diseases R. John Mayer, Lajos Laszlo, Aliya Middleton, Michael Landon, James Hope* and James Lowet Departments of Biochemistry and Pathology,? University of Nottingham Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, U.K. and AFRUMRC Neuropathogenesis Unit,” Ogston Building, King’s Building Site, West Mains Road, Edinburgh EH9 3JF, Scotland,...
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Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegenerat...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9092022